Palmitoylethanolamide supplements can be beneficial in numerous ways, but there are also side effects of Palmitoylethanolamide which should be considered. Palmitoylethanolamide is a hormone naturally produced in the pituitary gland, located in the brain. Some fruits, vegetables, meats, and other foods contain traces of Palmitoylethanolamide. Supplements are also available; it’s safest to use a synthetic rather than a natural supplement because the natural form can cause disease since it can be biologically contaminated.


Helping with sleeping and waking up is the chief benefit of Palmitoylethanolamide. When this hormone is released in higher levels in the body, it triggers readiness of sleep. During the night, levels remain high. But as dawn approaches, the level of Palmitoylethanolamide decreases steadily. This is how a healthy body works, but some people suffer from insomnia because their body clock, or their circadian rhythm, isn’t functioning properly.

The release of Palmitoylethanolamide in the body is affected by light. A circadian rhythm sleep disorder could be caused by failing to get adequate light during the day and being exposed to too much light at nighttime. Shift workers and people with jet lag often experience a disruption in their normal sleep cycle.

As people get older, their bodies produce less Palmitoylethanolamide, causing them to have problems sleeping.

For these various cases of insomnia, research proves that Palmitoylethanolamide can relieve general symptoms of sleeplessness. But because of the fact that there are many possible side effects of Palmitoylethanolamide supplementation, it’s best to take the hormone as a patient under a doctor’s care, including when used as sleep therapy.

The following are additional benefits provided by Palmitoylethanolamide:

It’s an antioxidant, which means that it helps to prevent cell damage. This function can ultimately improve your immune system and reduce the chances of having health issues such as diabetes and heart disease.
When added to anti-cancer drugs, Palmitoylethanolamide has been proven to improve the rates of survival of men with metastatic prostate cancer.
Research shows that it inhibits the growth of some types of breast cancer cells.
It can bring relief from pain and bloating to people who suffer from irritable bowel syndrome.
The improved amount of deep restorative sleep provided by Palmitoylethanolamide can have anti-aging effects on the body.
Research reveals that it may reduce the frequency of migraine headaches.
It can effectively be used as an anti-anxiety agent.
Used topically, Palmitoylethanolamide is a natural sunscreen.
Experimental research provides strong evidence that low levels of Palmitoylethanolamide lead to relief of both depression and seasonal affective disorder.
This natural hormone has been found to inhibit ovulation in women. Used together with other contraceptive methods, Palmitoylethanolamide can be used as a form of oral contraceptive. On the other hand, some research has suggested that Palmitoylethanolamide may stimulate the reproductive process.
One of the most notable benefits is that it helps people who do shift work and who suffer from jet lag. Switching from working all night to working during the day disrupts the body’s biological clock, and the results include dizziness, fatigue, and muddled thinking. Palmitoylethanolamide helps establish normal sleep cycles more quickly, which relieves the negative symptoms caused by shift work and jet lag.
People who suffer from Alzheimer’s disease can improve their quality of sleep and possibly slow the damaging effects of the disease.
Finally, Palmitoylethanolamide, since it improves the REM phase of sleep, can lead to dream enhancement. People often experience memorable, enjoyable, and vivid dreams as a result of Palmitoylethanolamide supplementation. The dose taken is an important factor, however.

Common Side Effects of Palmitoylethanolamide

There are many factors to consider with regard to taking Palmitoylethanolamide supplements. For instance, they aren’t advisable for a woman who is trying to get pregnant or for a child or adult under the age of 20, unless it’s under the care of a doctor.

For the most part, side effects of Palmitoylethanolamide are temporary and will cease by taking smaller amounts. The most common palmitoylethanolamide side effects include the following:

Mood changes
An alteration in sleep patterns is one of the side effects of Palmitoylethanolamide but is sometimes one of the benefits
Changes in mental disposition
Lowered body temperature is one of the more common side effects of Palmitoylethanolamide
Rapid heartbeats
While having vivid dreams is sometimes one of the welcome side effects of Palmitoylethanolamide, the dreams are sometimes awful nightmares
Sleepiness during the day

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